Seroprevalence of human fasciolosis in a new-emerging focus of fasciolosis in Yasuj district, Southwest of Iran

Fasciolosis is an important health and veterinary problem in Iran. The epidemiological pattern of disease has been changed markedly in recent years and there are regions that have potent capacity to be new focus of the disease. One of these areas is Yasuj district in Southwest of Iran where animal fasciolosis has been quite common. The current study was conducted to determine the seroprevalence of human fasciolosis in this area and to reveal the epidemiological factors associated with the spreading of the disease in this region. One thousand blood samples were randomly collected from five villages in Yasuj district. ELISA, using Fasciola somatic antigen [SA], was carried out to detect anti Fasciola antibodies in the collected sera. Anti-Fasciola antibodies were detected in serum of 18[1.86%] individuals by ELISA. Out of 18 seropositive people, 9 [0.9] were female and 9 [0.9%] were male. Most of people [99.8%] had a history of consuming wild freshwater plants mainly Nasturtium microphyllum [local name Bakaloo] and/or Mentha logifolia [local name Pooneh]. No significant correlation was found between seropositivity to fasciolosis and sex, age, history of consumption of green leafy aquatic plants whereas correlation between seropositivity and abdominal pain was significant [P< 0.05]. Results of this study showed that the seroprevalence rate of human fasciolosis in Yasuj district is relatively high and this area can be considered as a new emerging focus of the disease in Iran

[ case of idiopathic CD4+ lymphocytepenia]

Opportunistic infections are common in patient with cell mediated immunodeficiency. We report here a case of multiple opportunistic infections and lymphoproliferative disease in patient eith idiopathic cd4+ lymphocy topenia. A 45 years old man was admitted in our hospital due to respiratory distress and diffuse skin lesions

BX of skin lesions and cdture of synovied fluid contained TB infection and prepared smear of synovid fluid contained aspergilus. The white blood cde count was 1000/ml with pmn [63%] and lymphocyte[28%] and cd4 [10.4%]. persistent cd4+ lymphocy to penia below 300/ml and lack of evidence for HIV1, 2 infection and also HTLV1, 2 infection svggests that immunosupression was due to idiopathic cd4+ lymphocytopenia [ICL] the paticnt was treated with antifungal and antibiotics and clinically improved. One years lates he almittes due to left side paresis. In brain MRI a lesion was seen in frontal. Also there was multiple lymph in inguinal region. Biopsy of lymph node showed lympo proliferative disordes. Unfortunately despite treatmen he died